Darlene McCord - Research on Alzheimer's
Alzheimer's Disease is the most common form of dementia. The Alzheimer's Association estimates that 5.4 million people were living with Alzheimer's disease in 2011. Alzheimer's is characterized by the break down of proteins in the brain that disrupt the electrical firing of the brain, thus causing a decrease in brain function.
While many people believe that dementia is a fixture of aging, evidence suggests that steps can be taken to effectively reduce one's risk of dementia. Current findings suggest that lifestyle changes and a proper intake of nutrients could reduce one's risk of dementia.
Oxidative stress is a kind of cellular level damage that can have serious health-effecting consequences. Oxidative stress is caused by the build-up of harmful free radicals and reactive oxygen species (ROS) within the cell. Antioxidants bind to and quench ROS and free radicals reducing their ability to damage the cell.
Olivamine10™ is a proprietary blend of several antioxidants, invented by biochemist, Dr. Darlene McCord. Its main ingredient is the powerful antioxidant pulled from the olive, hydroxytyrosol. It contains L-cysteine and glycine, which gives the body the components it needs in order to make glutathione, which works against oxidative stress. It also has several protective amino acids and other antioxidants. Today scientists are beginning to understand that oxidative stress damage accumulated over time can cause or speed the progression of several diseases.
Oxidative Stress and Alzheimer's.
The brain has a lower tolerance for ROS than the rest of the body because it is especially dependent upon oxygen to carry out its duties. Post-mortem studies of Alzheimer's patient's brains show a high level of oxidative stress-induced damage.1, 2 N-acetyl-L-cysteine (NAC), when paired with Lipoic Acid (LA), protected mitochondrial function within Alzheimer's cell lines.3 Both NAC and LA can be found in Pinnaclife's Multivitamin invented by Dr. Darlene McCord.
Another study found that orally administered NAC in mice with Alzheimer's significantly reduced chemical markers associated with advanced Alzheimer's disease. The mice receiving this treatment also demonstrated increased memory performance. This suggests that NAC may reduce Alzheimer's-induced brain nervous damage and improve memory loss.4
Why You May Need Magnesium.
The hippocampus is the part of the brain that is involved in the formation of memories, emotion, and the ability to learn. As Alzheimer's disease progresses, the hippocampus experiences a severe depletion of magnesium.5 It is believed that this magnesium depletion decreases the ability of certain cellular gates to work within the brain. Other evidence suggests that magnesium acts to protect neurons within the brain. It is believed that magnesium depletion, and the consequential loss of neuronal protection, significantly contributes to the degradation of neurons within the brain of an Alzheimer's patient.6
The brain and its neural circuitry contain high concentrations of omega-3 to help them function. It is believed that omega-3 protect and facilitate both the synapses and the neuronal function of the brain, improving brain function.7
Darlene McCord Products
- Pinnaclife D3 + Magnesium
- Pinnaclife Multivitamin
- Pinnaclife Products were developed by Dr. Darlene McCord - Darlene McCord is a leading researcher at McCord Research.
*The statements and products in this article have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.
- Valko, M. et al. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry 39, 44-84 (2007).
- Reddy, V.P. et al. The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease. Molecular Neurobiology 535-544 (2005).
- Moreira, P.I. et al. Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts. Journal of Alzheimer's disease : JAD 12, 195-206 (2007).
- Fu, A.-L., Dong, Z.-H. & Sun, M.-J. Protective effect of N-acetyl-L-cysteine on amyloid beta-peptide-induced learning and memory deficits in mice. Brain research 1109, 201-6 (2006).
- Durlach, J. Magnesium depletion and pathogenesis of Alzheimer's disease by Jean Durlach. Magnesium Research 3, 217-218 (1990).
- Lemke, M.R. Plasma Magnesium Decrease and Altered Calcium / Magnesium Ratio in Severe Dementia of the Alzheimer Type. Biol Psychiatry 3223, (1995).
- Bazan, N.G., Musto, A.E. & Knott, E.J. Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. Molecular Neurobiology 44, 216-22 (2011).